Research progress on lipid metabolism related pathways of primary hepatic carcinoma and intervention with medicines
10.3760/cma.j.cn113884-20230207-00032
- VernacularTitle:原发性肝癌脂代谢相关通路及药物干预的研究进展
- Author:
Yuhe HU
1
;
Xianghua LIU
;
Yilong SUN
;
Ruoxi WANG
;
Shan LI
Author Information
1. 河南中医药大学第一临床医学院，郑州 450046
- Keywords:
Liver neoplasms;
Lipid metabolism;
Signaling pathway;
Drug intervention
- From:
Chinese Journal of Hepatobiliary Surgery
2023;29(10):788-792
- CountryChina
- Language:Chinese
-
Abstract:
Primary hepatic carcinoma, hepatic carcinoma for short, is a common gastrointestinal tumor with an insidious onset and rapid progression, and its incidence rate is increasing year by year, seriously threatening the life and health of our people. At present, there is still a lack of specific markers for early diagnosis and treatment of hepatic carcinoma, so the research on its biological characteristics and pathogenesis has become very urgent. Metabolic reprogramming is one of the main characteristics of tumor cells, and lipid metabolic reprogramming is involved in the occurrence and development of hepatic carcinoma. Therefore, the key metabolic enzymes and regulatory molecules in the process of lipid metabolism are considered as important targets for the diagnosis and treatment of hepatic carcinoma. This paper mainly focuses on the signaling pathways and regulatory molecules related to hepatocellular carcinoma lipid metabolism, as well as the related anti-hepatoma drugs, so as to provide new ideas for the prevention and treatment of hepatic carcinoma.
