Analysis of risk factors for newly developed non-alcoholic fatty liver after pancreaticoduodenectomy based on a propensity score matching study
10.3760/cma.j.cn113884-20230618-00170
- VernacularTitle:基于倾向性评分匹配的胰十二指肠切除术后新发非酒精性脂肪肝的危险因素分析
- Author:
Wei JIANG
1
;
Shuqi MAO
;
Jingshu TONG
;
Hongchao MI
;
Caide LU
Author Information
1. 宁波市医疗中心李惠利医院肝胆胰外科，宁波 315041
- Keywords:
Pancreaticoduodenectomy;
Non-alcoholic fatty liver disease;
Propensity score matching
- From:
Chinese Journal of Hepatobiliary Surgery
2023;29(10):721-726
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the risk factors of newly developed non-alcoholic fatty liver disease (NAFLD) after pancreaticoduodenectomy (PD) based on a propensity score matching (PSM) analysis.Methods:The clinicopathological data of 219 patients with pancreatic or periampullary tumors undergoing PD in the Ningbo Medical Center Lihuili Hospital from December 2015 to December 2021 were retrospectively analyzed, including 129 males and 90 females, aged (63.68±11.07) years old. The patients were divided into two groups according to the newly occurrence of NAFLD within one year after PD: the NAFLD group ( n=57) and non-NAFLD group ( n=162). A caliper value of 0.1 was employed for 1∶1 matching, resulting in a well-balanced PSM between the groups. Results:A total of 144 patients were successfully matched by PSM. Univariate analysis indicated that gender, body mass index, preoperative serum triglyceride and operative time were risk factors for newly developed NAFLD after PD. Multivariate analysis showed that female ( OR=6.493, 95% CI=2.631-16.129, P<0.001), preoperative serum triglycerides ≥1.5 mmol/L ( OR=3.055, 95% CI=1.220-7.654, P=0.017) and operative time ≥300 min ( OR=5.092, 95% CI=1.374-18.865, P=0.015) were the independent risk factors for newly developed NAFLD after PD. Conclusion:Based on PSM analysis, female, preoperative triglyceride ≥1.5 mmol/L and operative time ≥300 min were independent risk factors for newly developed NAFLD after PD.
