Clinical features and risk factors of multi-drug resistant bacteria infection after liver transplantation
10.3760/cma.j.cn113884-20230227-00055
- VernacularTitle:肝移植术后多重耐药菌感染特点及危险因素分析
- Author:
Dong WANG
1
;
Shun ZHOU
;
Yong WANG
;
Changxian LI
;
Xiangcheng LI
Author Information
1. 南京医科大学第一附属医院肝胆中心，南京 210029
- Keywords:
Liver transplantation;
Multi-drug resistant bacteria infection;
Risk factors
- From:
Chinese Journal of Hepatobiliary Surgery
2023;29(9):646-650
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical features and related risk factors of multi-drug resistant organism (MDRO) infection after liver transplantation, so as to guide clinical identification of high-risk patients and reduce the occurrence of MDRO infection.Methods:Of 187 patients undergoing liver transplantation in the First Affiliated Hospital of Nanjing Medical University from February 2019 to September 2020 were enrolled, including 150 males and 37 females, aged (50.6±9.6) years. Data related to MDRO infection were collected, and independent risk factors were identified using univariate analysis and multiple logistic regression analysis.Results:Among the 187 patients, MDRO infection occurred in 39, and 9 patient deaths were directly related to MDRO infection. Lung is the most common infection site, accounting for 82.1% (32/39) of MDRO infection. The most common pathogenic bacteria were Acinetobacter baumannii and Carbapenem-resistant enterobacteriaceae, accounting for 46.8%(36/77) and 41.7%(32/77) of MDRO infection, respectively. Multiple logistic regression analysis showed that postoperative mechanical ventilation ≥ 48 h ( OR=3.430, 95% CI: 1.124-10.467, P=0.030), intensive care unit (ICU) stay ≥7 d ( OR=9.013, 95% CI: 3.054-26.594, P<0.001) were independent risk factors of postoperative MDRO infection. Conclusions:Early removal of endotracheal intubation and discharge from ICU are important to reduce the risk of MDRO infection after liver transplantation.
