Research progress in histone acetylation in radiation-related DNA damage

VernacularTitle:组蛋白乙酰化在放疗相关DNA损伤中的研究进展
Author: Jingyi FENG ¹ ; Heying YAO ; Haitao ZHU ; Wei JIANG ; Xiang LIAO
Author Information

1. 江苏大学附属医院放射科，镇江　210031
Keywords: Radiotherapy; Histones; Epigenetic modification; Acetylation; DNA damage
From: Chinese Journal of Radiation Oncology 2024;33(4):378-382
CountryChina
Language:Chinese
Abstract: Radiotherapy is a first-line treatment for a variety of malignant tumors by inducing DNA damage to kill tumor cells. However, tumor cells have different sensitivities to radiotherapy, ultimately leading to different therapeutic effects. Histone acetylation, regulated by histone acetyltransferase (HAT) and histone deacetylase (HDAC), is involved in the regulation of cell radiation sensitivity by influencing DNA damage repair. The main mechanisms are recruiting DNA repair related proteins and mediating chromatin dynamic changes. In this article, the role of histone acetylation modification in tumor radiotherapy was reviewed, aming to provide the basis for the radiotherapy sensitization strategy based on histone acetylation.