Hypotensive Effect of Perindopril in Patients with Essential Hypertension.
10.4070/kcj.1991.21.2.337
- Author:
Jong Hoa BAE
;
Heung Sun KANG
;
Kwon Sam KIM
;
Myung Shick KIM
;
Jung Sang SONG
- Publication Type:Original Article
- Keywords:
Hypertension;
Perindopril
- MeSH:
Blood Pressure;
Cough;
Dizziness;
Dyspepsia;
Heart Rate;
Humans;
Hypertension*;
Male;
Perindopril*
- From:Korean Circulation Journal
1991;21(2):337-341
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To evaluate the effect of Perindopril in patients with essential hypertension, we administered Perindopril 4 to 8mg/day once daily to 30 patients(18 males, 12 females) for 12 weeks. Baseline blood pressure after 4 weeks with placebo was 150.4+/-7.5/102.0+/-4.3mmHg. The blood pressures of the patients were declined significantly at 4th(140.6+/-14.9/95.4+/-6.5), 8th(136.7+/-11.4/91.7+/-7.6), and 12th(132.3+/-11.1/87.5+/-6.9) week(p<0.01) without change of heart rate. The blood pressure of the patients was normalized below 140/30mmHg in 24 patients(80%) and declined diastolic blood pressure more than 10mmHg in one patients. Therefore the response rate of perindopril was 83.3%. There were reported 3 patients who revealed mild adverse reactions as follows; cough, indigestion, dizziness in one each. In conclusion, these results indicate that antihypertensive therapy with perindopril single daily dose was effective in patients with mild to moderate essential hypertension and well tolerated.
