Performance evaluation of Ethos intelligent optimization engine in automatic plan generation
10.3760/cma.j.cn113030-20230403-00064
- VernacularTitle:Ethos智能优化引擎在宫颈癌自动计划生成中的性能评估
- Author:
Zhiqun WANG
1
;
Bo YANG
;
Xiangyin MENG
;
Yongguang LIANG
;
Tingtian PANG
;
Xingliu WANG
;
Xiaoshen WANG
;
Hongying LUO
;
Jiawei CHEN
;
Fuqiang CHEN
;
Zongkai ZHOU
;
Zhen ZHANG
;
Jie QIU
Author Information
1. 中国医学科学院北京协和医学院北京协和医院放疗科，北京 100730
- Keywords:
Radiotherapy, online adaptive;
Intelligent optimization engine;
Automatic optimization
- From:
Chinese Journal of Radiation Oncology
2024;33(4):339-345
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the automatic optimization performance and clinical feasibility of the intelligent optimization engine (IOE) in the Ethos online adaptive radiotherapy platform.Methods:Clinical data of 11 patients with postoperative cervical cancer treated with Halcyon accelerator were retrospectively analyzed. Manual planning was performed for all patients using the 4 full arc volumetric modulated arc therapy (VMAT) (Manual-4Arc) in Eclipse, with a prescription dose of 45 Gy/25F. Patient images and structures were imported into the Ethos simulator, and appropriate clinical goals were added based on clinical requirements. The target coverage was normalized to 95%. Automatic plan generation was conducted using IOE, resulting in 7, 9, and 12 field intensity modulated radiotherapy (IMRT) plans (IMRT-7F、IMRT-9F、IMRT-12F), as well as 2 and 3 arc VMAT plans (VMAT-2Arc、VMAT-3Arc). Dosimetric index comparisons were made between the Manual-4Arc plans and the 5 groups of IOE-generated plans through one-way analysis of variance. Based on the analysis results, Turky post hoc multiple comparisons were performed to evaluate the automatic optimization performance of IOE.Results:In terms of the high dose area, the IMRT-12F plans showed the lowest D 1% for the planning target volume (PTV), and there were significant differences compared to the Manual-4Arc plans ( P=0.004). Regarding target coverage, all groups produced clinical target volume (CTV) plans that met the clinical requirements. Although the Ethos online adaptive plans were normalized during planning, the PTV coverage was slightly insufficient. For organs at risk (OAR) close to the target, such as the bladder, there were significant differences in V 30 Gy, V 40 Gy, and D mean among the 6 groups of plans. The dose ranking for the bladder was generally as follows: IMRT-12F
