Advances in the study of increased malignant potential of tumor cells after radiation
10.3760/cma.j.cn113030-20221109-00376
- VernacularTitle:放射后肿瘤细胞恶性潜能增加的研究进展
- Author:
Jiewen ZHANG
1
;
Fei LU
;
Linping LEI
;
Hui SONG
;
Li CHANG
Author Information
1. 昆明医科大学第三附属医院/云南省肿瘤医院放射治疗科，昆明 650118
- Keywords:
Neoplasms / radiotherapy;
Epithelial-mesenchymal transition;
Circadian rhythm;
Cellular senescence;
Stemness of cancer cell
- From:
Chinese Journal of Radiation Oncology
2023;32(11):1025-1029
- CountryChina
- Language:Chinese
-
Abstract:
Radiotherapy is an effective anti-tumor therapy for different types of solid tumors. Over 50% of cancer patients are treated with radiotherapy at different stages in the course of the disease. According to traditional radiobiology, radiation therapy mainly kills tumor cells by causing proliferative death of tumor cells through DNA damage. However, clinical data showed that many patients still experienced tumor recurrence and metastasis after receiving radiation therapy. Current studies have found that the biological behavior of tumor cells, such as invasion and migration, were changed after radiation through epithelial-mesenchymal transition, circadian rhythm disruption, senescence, and increased stemness of cancer cells, thereby leading to tumor recurrence and metastasis. In this article, the changes and mechanisms of biological behavior in tumor cells after radiation were reviewed, providing evidence for the prevention and treatment of tumor recurrence and metastasis.
