Heterogeneity of cancer-associated fibroblasts and regulating roles in cancer radiotherapy
10.3760/cma.j.cn113030-20230321-00054
- VernacularTitle:肿瘤相关成纤维细胞异质性及其在放射治疗中的调控作用
- Author:
Meihua CHEN
1
;
Shubin WANG
;
Jinyi LANG
Author Information
1. 四川省肿瘤医院·研究所放疗科，放射肿瘤学四川省重点实验室，四川省癌症防治中心，四川省肿瘤临床医学研究中心，电子科技大学附属肿瘤医院，成都 610041
- Keywords:
Cancer-associated fibroblasts;
Heterogeneity;
Radiotherapy;
Tumor microenvironment;
Radiosensitivity
- From:
Chinese Journal of Radiation Oncology
2023;32(11):1020-1024
- CountryChina
- Language:Chinese
-
Abstract:
Cancer-associated fibroblasts (CAF) represent a crucial and abundant group of stromal cells in the tumor microenvironment (TME) and are effective targets for anti-tumor therapy. CAFs exhibit high heterogeneity and plasticity, which play a pivotal role in tumor initiation, progression, immune evasion, and therapy resistance. Radiotherapy (RT) is a fundamental treatment modality for malignant tumors that can reshape the TME through various mechanisms. Following RT, CAFs undergo a series of phenotypic changes and interact with multiple cells in the TME, promoting radioresistance and immune evasion through multiple pathways, such as enhancing tumor cell proliferation, modulating immune response, inducing angiogenesis, remodeling extracellular matrix, and reprogramming metabolism, etc., thereby affecting therapeutic effect. Targeting CAFs in combination with RT can improve anti-tumor efficacy and prognosis. In this article, research progress in CAFs in tumor RT was reviewed.
