Research progress on the effect of hyperthermia on cancer-associated fibroblasts in tumor microenvironment

VernacularTitle:热疗对肿瘤微环境中肿瘤相关成纤维细胞作用的研究进展
Author: Yun SHAO ¹ ; Yuli HAO ; Yuan CONG ; Pei SHEN ; Xuexiao ZHOU ; Shengzhi WANG
Author Information

1. 青岛大学口腔医学院，青岛　266003
Keywords: Neoplasms / thermal therapy; Tumor microenvironment; Cancer-associated fibroblasts; Tumor immune microenvironment
From: Chinese Journal of Radiation Oncology 2023;32(10):945-950
CountryChina
Language:Chinese
Abstract: Tumor microenvironment possesses immunosuppression characteristics via the mechanism of inducing tumor cell immune escape. The interaction between tumor cells and tumor microenvironment is an important factor affecting tumor genesis and development. As an important part of tumor microenvironment, cancer-associated fibroblasts interact directly or indirectly with tumor cells and produce various cytokines to regulate tumor immune microenvironment. In recent years, hyperthermia has become an auxiliary means of anti-tumor therapy. With the development of research on tumor hyperthermia and tumor microenvironment, a large number of studies have found that hyperthermia can regulate cancer-associated fibroblasts in tumor microenvironment. In this article, recent research progresses of the effects of hyperthermia on cancer-associated fibroblasts and related cells and cytokines in tumor microenvironment were reviewed, providing a new way for clinical application of hyperthermia combined with immune or targeted therapy.