Research progress in the mechanism of abscopal effect induced by radiation
10.3760/cma.j.cn113030-20220822-00285
- VernacularTitle:辐射诱导远隔效应机制的研究进展
- Author:
Yuting GAO
1
;
Pengfei LI
;
Guorong MA
;
Jiahao ZHANG
;
Linjing LI
;
Xiaodong JIN
;
Yuan LI
Author Information
1. 中国科学院近代物理研究所，兰州 730000
- Keywords:
Neoplasms;
Radiotherapy;
Abscopal Effect;
Molecular mechanism
- From:
Chinese Journal of Radiation Oncology
2023;32(9):861-865
- CountryChina
- Language:Chinese
-
Abstract:
Radiotherapy combined with immunotherapy for the treatment of cancer can induce stronger abscopal effect (AE) and inhibit the growth of tumors outside of radiation field, but the occurrence of AE is distinctly uncommon and unpredictable in clinical practice. The complex molecular mechanism underlying AE remains to be in-depth understood. It has been reported that some new factors are involved in the regulation of AE induced by radiation, but the molecular mechanism has not been fully unravelled. In this article, the roles of macrophages, tumor draining lymph node, p53 and exosomes in the new mechanisms of AE were reviewed, aiming to provide a theoretical basis for the development of more effective cancer therapeutics.
