Role of senescence-associated secretory phenotype-related premature senescence in ionizing radiation-induced damage to vascular endothelial cells
10.3760/cma.j.cn112271-20230718-00005
- VernacularTitle:衰老相关分泌表型引起的早衰在电离辐射诱导血管内皮细胞损伤中的作用
- Author:
Ruhan YI
1
;
Mengmeng LIU
;
Jie CHEN
;
Chen LI
;
Ling GAO
;
Qingjie LIU
Author Information
1. 中国疾病预防控制中心辐射防护与核安全医学所 辐射防护与核应急中国疾病预防控制中心重点实验室，北京 100088
- Keywords:
Senescence-associated secretory phenotype (SASP);
Cellular senescence;
Vascular endothelial cell;
Ionizing radiation
- From:
Chinese Journal of Radiological Medicine and Protection
2024;44(3):240-246
- CountryChina
- Language:Chinese
-
Abstract:
Radiation-induced damage to vascular endothelium is a major complication of radiotherapy and a primary cause of morbidity and mortality in the population exposed to radiation. Ionizing radiation-induced cellular senescence serves as a critical factor in damage to vascular endothelial cells. Therefore, understanding the mechanisms of cellular senescence caused by senescence-associated secretory phenotype (SASP), as well as its role in ionizing radiation-induced damage to vascular endothelial cells, is significant for preventing and treating ionizing radiation-induced damage to vascular endothelial cells. In this study, the relationship between SASP-related premature senescence and this ionizing radiation-induced damage was explored from the following aspects: the mechanisms behind ionizing radiation-induced damage to vascular endothelial cells, ionizing radiation-induced cellular senescence, and the role of SASP-related premature senescence in the ionizing radiation-induced damage to vascular endothelial cells, as well as potential targets.
