Advances in research on the application of organoids in radiotherapy

VernacularTitle:类器官在放射治疗中应用的研究进展
Author: Peiyu GUO ¹ ; Yiqing MO ; Ruixue HUANG
Author Information

1. 中南大学湘雅公共卫生学院劳动与环境卫生系，长沙　410078
Keywords: Organ; Organoid; Model; Radiotherapy; Radiological medicine
From: Chinese Journal of Radiological Medicine and Protection 2024;44(1):72-77
CountryChina
Language:Chinese
Abstract: With the extensive applications of nuclear energy in the military, scientific research, and medical fields, radiological medicine has developed into a significant discipline. So far, studies of radiology have been conducted mostly using cell and animal models, both of which have limitations. Organoids, as 3D in vitro culture systems derived from tissue stem cells, have filled the gap left by these conventional models. They have been widely applied in review, disease research, drug development, and cancer modeling since their structures, functions, and genetic characteristics are akin to those of primary tissues. This review presents the applications of organoid models of various organ types in radiotherapy, as well as the limitations and prospects of organoids.