Advances in research on radiation-induced brain injury

VernacularTitle:放射性脑损伤的研究进展
Author: Lijing ZENG ¹ ; Huang XIA ; Yuxin CHEN ; Peiyue LIN ; Jing YANG ; Wenyi ZENG ; Xiaobo LI ; Benhua XU ; Rong ZHENG
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1. 福建医科大学附属协和医院放疗科　福建省肿瘤智能影像与精准放疗重点实验室　福建省消化、血液系统与乳腺恶性肿瘤放射与治疗临床医学研究中心，福州　350001
Keywords: Radiation-induced brain injury; Radiotherapy; Astrocyte; Gut microbiota
From: Chinese Journal of Radiological Medicine and Protection 2024;44(1):65-71
CountryChina
Language:Chinese
Abstract: Radiotherapy can cause functional and morphological changes in the brain tissues of patients with primary or metastatic malignant brain tumors, leading to radiation-induced brain injury. However, the pathogenesis of radiation-induced brain injury has not yet been unanimously determined, and its research advances and treatment protocols are yet to be elucidated and improved. In this study, we explore the pathogenesis of radiation-induced brain injury from the perspective of vascular injury, inflammatory reactions, neuronal dysfunction, glial cell injury, and gut microbiota and reviewed the advances in research on its treatment and prevention. The purpose is to provide a reference and theoretical basis for the research and clinical diagnosis and treatment of radiation-induced brain injury.