Radiation protection in clinical application of yttrium-90-loaded resin microsphere therapy
10.3760/cma.j.cn112271-20230526-00163
- VernacularTitle:90Y树脂微球治疗在临床应用中的放射防护研究
- Author:
Jiawu FENG
1
;
Jingzhi SUN
;
Shaojia WANG
;
Li ZHANG
;
Xuan ZHOU
;
Ruijie LING
Author Information
1. 湖北省中西医结合医院（湖北省职业病医院）职业卫生科，武汉 430015
- Keywords:
Yttrium-90 resin microsphere;
Radiation protection;
Dose equivalent rate
- From:
Chinese Journal of Radiological Medicine and Protection
2024;44(1):36-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the radiological protection measures for yttrium-90 ( 90Y)-loaded resin microsphere therapy in clinical application. Methods:The surgical operation process for 90Y-loaded resin microsphere therapy was simulated, involving measurement of ambient dose equivalent rates at various stages: preoperative preparation (dominated by drug package), drug transfer, intraoperative procedures (drug operation and injection), and postoperative care and observation within the hospital. Based on the simulation, the protection measures in clinical application were analyzed. Results:The dose equivalent rate ranged from 0.12 to 0.42 μSv/h around the active chamber and from 1.04 to 3.32 μSv/h in the fume hood. Around the digital subtraction angiography (DSA) room, the maximum dose equivalent rate was 0.78 μSv/h when 90Y and DSA were applied simultaneously and 0.36 μSv/h when 99Tc m and DSA were applied. For the first operating position in the fluoroscopy protection area, the maximum dose equivalent rate was 13.19 μSv/h at 155 cm height when only 90Y was applied, and 315.01 μSv/h at 80 cm height when 90Y and DSA were applied. For the second operating position, the maximum dose equivalent rate was 6.28 μSv/h at 155 cm height when only 90Y was applied and 291.03 μSv/h at the same height when 90Y and DSA were applied. The dose-equivalent rates ranged from 0.11 to 0.58 μSv/h around the dedicated ward for postoperative patients. Conclusions:The existing shielding measures, such as those in the nuclear medicine department and interventional room, meet the radiation protection requirements for 90Y-loaded resin microsphere therapy. However, it is still necessary to conduct a scientific assessment based on the actual situation. Additionally, radiation protection measures and surface contamination treatment should be enhanced during drug operation.
