Application of adaptive aperture in proton radiotherapy for brain tumors
10.3760/cma.j.cn112271-20230530-00166
- VernacularTitle:自适应多叶光栅在脑肿瘤质子放疗中的应用
- Author:
Weiqing WU
1
;
Xianglin YUAN
;
Guangyuan HU
;
Renchao ZHENG
;
Qianxia LI
;
Fei LIU
;
Xiaoguang LU
Author Information
1. 华中科技大学同济医学院附属同济医院肿瘤科，武汉 430030
- Keywords:
Brain tumor;
Adaptive aperture;
Proton;
Radiotherapy
- From:
Chinese Journal of Radiological Medicine and Protection
2024;44(1):24-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical application value of the adaptive aperture by comparing intensity-modulated proton radiotherapy(IMPT) plans using and not using the aperture for brain tumors.Methods:A total of twenty patients treated with postoperative radiotherapy for brain tumors were enrolled in this study. IMPT plans were developed for each patient using and not using the adaptive aperture under the same optimization conditions. The target conformal index (CI) value, target homogeneity index (HI) value, and the dose to normal tissues of the two sets of plans were compared.Results:The IMPT plans designed using the adaptive aperture significantly increased the mean CI value from 0.58 to 0.66, while decreasing the mean 50% prescription dose volume from 797.70 cm 3 to 638.15 cm 3. These plans also reduced the irradiation doses to the cochlea, brainstem, optic chiasm, optic nerve, and lens ( t = 2.06, 3.02, 2.11, 2.58, 2.67, P < 0.05). Additionally, there was no significant difference in the HI value of the target volumes and the machine jumps (MU) between the two sets of plans ( P > 0.05). Conclusions:The adaptive aperture can significantly reduce the irradiation dose to normal tissues outside the target volumes, positively impacting the protection of organs at risk (OARs) around the target values. This demonstrates its great potential for clinical application.
