Exploring the prognostic value of platelet-lymphocyte ratios for esophageal cancer patients based on propensity score matching
10.3760/cma.j.cn112271-20231007-00106
- VernacularTitle:基于倾向性评分匹配分析血小板淋巴细胞比值对食管癌患者预后的预测价值
- Author:
Jing WANG
1
;
Chao CHENG
;
Xueli JIA
;
Fuli ZHANG
;
Jie LI
Author Information
1. 山西省肿瘤医院 中国医学科学院肿瘤医院山西医院 山西医科大学附属肿瘤医院放射治疗科，太原 030013
- Keywords:
Esophageal neoplasms;
Platelet-lymphocyte ratio;
Prognosis
- From:
Chinese Journal of Radiological Medicine and Protection
2023;43(12):974-978
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the prognostic value of platelet-lymphocyte ratio (PLR) for esophageal cancer patients based on propensity score matching.Methods:A retrospective analysis was conducted on the clinical data of 272 esophageal cancer patients in Shanxi Province Cancer Hospital from January 2012 to December 2018. The optimal cut-off value of PLR, which was determined using the Youden index, was used to classify patients into high- and low-PLR groups. Propensity score matching (PSM) was employed to reduce the selection bias of patients. The prognostic factors were analyzed through univariate and multivariate Cox regression. The Kaplan-Meier method and the Log-Rank test were adopted for survival analysis.Results:Cox univariate analysis shows that prognosis of esophageal cancer patients was related to gender, smoking history, TNM stage, body mass index (BMI), carcinoembryonic antigen (CEA), systemic immune-inflammation index (SII), lymphocyte-monocyte ratio (LMR) and PLR ( χ2=6.63, 7.08, 30.38, 10.40, 12.95, 13.21, 4.52, 4.06, 7.77, P < 0.05). The optimal cut-off value of PLR was 159.93. Before PSM, there existed statistically significant differences in SII and LMR between the high-PLR ( n = 103) and low-PLR groups ( n = 169) ( χ2=52.23, 3.51, P<0.05). After PSM, there existed no statistical difference in prognostic indicators between the high-PLR ( n=62) and low-PLR groups ( n=62), suggesting that both groups were comparable. As revealed by Cox multivariate analysis, TNM stage, BMI, CEA, and PLR were independent risk factors for the prognosis of esophageal cancer patients both before and after PSM. The survival time of patients in the high-PLR group was significantly shorter than that in the low-PLR group ( χ2=3.29, P < 0.05). Conclusions:PLR hold critical value in evaluating the prognosis of esophageal cancer patients. A higher PLR is associated with a shorter survival time. Individualized intervention for PLR may play a positive role in improving the prognosis of patients.
