Radiation chemistry effects on water molecules after ultra-high dose rate irradiation
10.3760/cma.j.cn112271-20230326-00094
- VernacularTitle:超高剂量率照射后水分子的辐射化学效应研究
- Author:
Hui LUO
1
;
Phyllis ZHANG
;
Nan LI
;
Ke CHOU
;
Chengliang YANG
;
Leijie MA
;
Hongchang LEI
;
Ronghu MAO
;
Shuai SONG
;
Hong GE
Author Information
1. 郑州大学附属肿瘤医院肿瘤放疗科，郑州 450008
- Keywords:
Ultra-high dose rate irradiation;
Water molecular;
Radiation chemistry effects;
Free radical;
Lipid peroxidation
- From:
Chinese Journal of Radiological Medicine and Protection
2023;43(11):900-905
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the radiation chemistry effects on water molecules after ultra-high dose rate (FLASH) and conventional irradiation.Methods:Both FLASH and conventional irradiation were applied to ultrapure water, with the hydroxyl radical yield in the homogeneous phase detected using electron paramagnetic resonance (EPR) and the hydrogen peroxide (H 2O 2) yield in the diffusion phase analyzed uuxing fluorescence probe. The liposome model was then established to investigate the radiation chemistry effect of FLASH and conventional irradiation in inducing lipid peroxidation. Results:Radiation chemistry reactions were observed in water molecules after irradiation. In the homogeneous phase, the yield of free radicals using FLASH irradiation is similar to those from conventional irradiation ( P>0.05). In the diffusion phase, the amount of H 2O 2 produced by FLASH irradiation was significantly lower than those from conventional irradiation ( t=0.49-12.81, P<0.05). The liposome model confirmed that conventional irradiation could significantly induce lipid peroxidation through the radiation chemistry effect in water molecules as compared with FLASH irradiation ( t=0.31-11.73, P<0.05). Conclusions:The radiation chemistry effect in water molecules after FLASH irradiation was significantly lower than that from conventional irradiation. This could be one of the mechanisms of FLASH effect.
