The biological mechanism and clinical application of boron neutron capture therapy

VernacularTitle:硼中子俘获治疗的生物学机制及临床研究进展
Author: Pengxiang CHEN ¹ ; Qingxu SONG ; Bo CHENG ; Yuchen LIU ; Tianyu LIU ; Yufeng CHENG
Author Information

1. 山东大学齐鲁医院肿瘤放疗科/中子医学中心，济南　250012
Keywords: Boron neutron capture therapy; 10B compounds; Precision treatment; Cancer
From: Chinese Journal of Radiological Medicine and Protection 2023;43(10):845-850
CountryChina
Language:Chinese
Abstract: Boron neutron capture therapy(BNCT), a promising radiotherapy, belongs to precision treatment for cancers. BNCT can accurately kill cancer cells and protect normal cells at the same time relying on 10B compounds with high efficacy. The research about developing new 10B compounds is in progress, and novel and efficient 10B compounds are emerging, which greatly facilitate broadening the advantages and efficacy of BNCT. Considering the mixed rays generated from the BNCT process, its biological effects on tumor cells are relatively complex, and related studies are still lacking. The molecular mechanisms underlying BNCT need to be elucidated further. BNCT has been applied in the treatment of malignant brain tumors, head and neck cancers, and malignant melanoma with favorable curative effects. This review mainly focuses on the development of 10B compounds, biological mechanisms, potential advantages, and clinical applications.