The efficacy and influencing factors analysis of excimer laser combined with drug-coated balloon in the treatment of femoropopliteal arteriosclerosis obliterans
10.3760/cma.j.cn112149-20231104-002346
- VernacularTitle:准分子激光联合药物涂层球囊治疗股腘动脉硬化闭塞症的疗效及影响因素分析
- Author:
Panfeng LI
1
;
Xiaojian LI
;
Guoquan WANG
;
Hao NIU
;
Shuiting ZHAI
Author Information
1. 阜外华中心血管病医院血管外科 河南省人民医院心脏中心，郑州 450018
- Keywords:
Arteriosclerosis obliterans;
Femoropopliteal artery;
Laser;
Drug-coated balloon;
Angioplasty
- From:
Chinese Journal of Radiology
2024;58(3):313-317
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy of excimer laser atherectomy (ELA) combined with drug-coated balloon (DCB) in the treatment of femoropopliteal arteriosclerosis obliterans (ASO) and its influencing factors.Methods:The clinical data of patients with femoropopliteal ASO treated by ELA combined with DCB from July 2019 to March 2022 were retrospectively analyzed, including technical success rate, ankle-brachial index(ABI), primary patency rate and freedom from target lesion revascularization (TLR) rate. Cox regression was applied to analyze the risk factors affecting the decline in the rate of primary patency and freedom from TLR.Results:All 82 patients were treated with ELA+DCB. The technical success was 91.5%. The post-operative ABI (0.73±0.13) was significantly higher than preoperative ABI (0.39±0.11) ( t=35.26, P<0.001). The 24-month cumulative primary patency and TLR-free rates were 64.1% and 76.8%, respectively. Lesion length>15 cm ( HR=2.57, P=0.047) and severe calcification ( HR=3.26, P=0.021) were associated with loss of primary patency. Having diabetes ( HR=5.24, P=0.010) and a single postoperative outflow tract ( HR=4.18, P=0.008) were associated with a decrease in TLR-free rates. Conclusions:ELA combined with DCB for femoropopliteal ASO is safe and has good intermediate efficacy. Lesion length>15 cm and severe calcification were independent risk factors for primary patency rate, and diabetes and a single postoperative outflow tract were independent risk factors for TLR-free rate.
