Hemodynamic characteristics of lenticulostriate artery in patients with cerebral small vessel disease: a 7.0 T MRI study
10.3760/cma.j.cn112149-20230222-00121
- VernacularTitle:7.0 T MRI对小血管病患者豆纹动脉血流动力学特征的研究
- Author:
Zhiye LI
1
;
Yuanbin ZHAO
;
Xiaoyan BAI
;
Xun PEI
;
Xue ZHANG
;
Binbin SUI
Author Information
1. 首都医科大学附属北京天坛医院 国家神经系统临床疾病研究中心 天坛神经影像研究中心 北京市神经外科研究所，北京 100070
- Keywords:
Magnetic resonance imaging;
Ultra high field;
Cerebral small vessel disease;
Hemodynamics
- From:
Chinese Journal of Radiology
2023;57(11):1174-1179
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the hemodynamic characteristics of the lenticulostriate artery (LSA) in cerebral small vessel disease (CSVD) patients with recent small subcortical infarcts (RSSI) using 7.0 T two-dimensional phase-contrast MRI (2D PC-MRI).Methods:A total of 16 CSVD patients with deep RSSI and 18 age-and sex-matched healthy controls (HC group) meeting the inclusion criteria were prospectively recruited from July 2021 to June 2022 at Beijing Tiantan Hospital, Capital Medical University. All participants underwent 7.0 T 2D PC-MRI with imaging plane localized at the level of the basal ganglia. A self-developed software (Flow analyze V1.0) was used to analyze the hemodynamic status of bilateral LSAs. The hemodynamic parameters including the maximum velocity (V max), average velocity (V avg), pulsatility index (PI), and resistance index (RI) of LSAs were calculated and recorded. As for the CSVD cases, the symptomatic side was defined as the ipsilateral side to the RSSI (CSVD symptomatic-side group), and the contralateral side was defined as the asymptomatic side (CSVD asymptomatic-side group). ANOVA or Mann-Whitney U test was used to compare hemodynamic parameters among the three groups. Results:Significant differences in V max, V avg and PI were observed among the CSVD symptomatic-side group, CSVD asymptomatic-side group, and HC group ( F=5.22, P=0.006; F=3.47, P=0.033; F=4.37, P=0.014). Specifically, CSVD symptomatic-side group showed significantly reduced V max ( P=0.004) and V avg ( P=0.017), and increased PI ( P=0.007) compared to the HC group. The CSVD asymptomatic-side group showed decreased V max ( P=0.026) and increased PI ( P=0.039) compared to the HC group. Conclusions:Hemodynamic assessment based on 7.0 T 2D PC-MRI reveal that CSVD patients with RSSI decrease blood flow velocity and increase arterial PI of LSAs. These findings suggest potential corresponding hemodynamic mechanisms associated with CSVD with RSSI lesions.
