Two case reports of rare antisynthetase syndrome and literature review
10.3760/cma.j.cn141217-20230118-00019
- VernacularTitle:少见型抗合成酶综合征2例并文献复习
- Author:
Dongbin JIANG
1
;
Yinli ZHANG
;
Wenjuan GUAN
;
Lei ZHANG
;
Hongling ZENG
;
Xin ZHANG
;
Shengyun LIU
;
Guanmin GAO
Author Information
1. 郑州大学第一附属医院风湿免疫科，郑州 450052
- Keywords:
Antisynthetase syndrome;
Anti-aminoacyl tRNA synthetase antibody;
Anti Zo antibody;
Anti Ha antibody;
Lung disease, interstitial
- From:
Chinese Journal of Rheumatology
2024;28(2):123-126
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical and immunological features of two case of rare antisynthetase syndrome (ASS), so as to improve the level of diagnosis and treatment.Methods:Two cases with rare antisynthetase syndrome admitted to the First Affiliated Hospital of Zhengzhou University from July 2020 to August 2022 were collected.Results:The two rare ASS were anti-Zo antibody and anti-Ha antibody positive patients, both of which had interstitial lung disease (ILD) as the main clinical manifestation and positive anti-Ro52 antibody. Two rare antisynthetase autoantibodies manifested cytoplasmic ANA indirect immunofluorescence (IIF) staining pattern, but it is different from the cytoplasmic dense speckled pattern of several common ASS antibodies. After treatment with glucocorticoids and immunosuppressants, case 1 died of respiratory failure due to a long course of disease and late diagnosis, the lung lesions of case 2 improved significantly.Conclusion:When encountering the cytoplasmic ANA fluorescent pattern in ILD patients, especially with anti-Ro52 antibody, it is necessary to screen more myositis specific antibodies to rule out the possibility of rare ASS.
