Analysis of the correlation between granulomatosis with polyangiitis and head and neck cancer
10.3760/cma.j.cn141217-20230529-00145
- VernacularTitle:肉芽肿性多血管炎与头颈癌关联分析
- Author:
Chenxi LI
1
;
Liping SU
;
Zhongcheng GONG
;
Weina ZHANG
Author Information
1. 新疆医科大学第一附属医院（附属口腔医院）颌面肿瘤外科 新疆维吾尔自治区口腔医学研究所，乌鲁木齐 830054
- Keywords:
Head and neck neoplasms;
Granulomatosis with polyangiitis;
Cohort studies;
TriNetX analytics network
- From:
Chinese Journal of Rheumatology
2023;27(12):793-798
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the risk of head and neck cancer in patients with newly or previously diagnosed granulomatosis with polyangiitis (GPA).Methods:All data were extracted from the TriNetX Analytics Network joint research platform. A total of 13 094 188 subjects with complete clinical follow-up information were included in the study. Patients were divided into the experimental group (GPA patients, n= 20 663) and the control group (non-GPA patients, n=13 073 525). Patients with the diagnosis of malignant tumors occurred in sinonasal/nasopharynx, oral cavity, oropharynx, and larynx/hypopharynx concurrently or after the initial encounter diagnosis of GPA were recorded. The characteristics of participants were stratified according to covariate (age, gender, race, HNC risk factor) and compared using one-way analysis of variance and chi-square test. Relevant confounding variables, including human papillomavirus, smoking, and alcohol exposure, were matched among stratified cohorts. COX proportional hazards model was used to calculate the hazard ratios ( HR) and corresponding 95% confidence interval ( CI) of HNC in two groups to evaluate the impact of GPA on the occurrence of HNC. Results:Of the patients within the GPA group, 22 (0.11%), 59 (0.29%), 15 (0.08%), and 18 (0.09%) had an encounter diagnosis of malignancy of the sinonasal/nasopharynx, oral cavity, oropharynx, and larynx, respectively. When comparing the patients of the experimental group with the standardized control population, the risk of developing nasal/nasopharyngeal malignancies in GPA patients was at least twice higher [ HR (95% CI)=2.20 (1.04, 4.65), P<0.001]. Conclusion:This study identified a statistically significant increase in the risk of sinonasal/nasopharyngeal cancer in patients with GPA. However, additional large-scale population investigations are still needed to confirm these correlation.
