The emerging role of blood lipoprotein levels in osteoporosis of postmenopausal women with rheumatoid arthritis
10.3760/cma.j.cn141217-20221030-00449
- VernacularTitle:绝经后女性类风湿关节炎中脂蛋白水平在骨质疏松症中的新兴作用
- Author:
Zong JIANG
1
;
Xiaoling YAO
;
Fang TANG
;
Wukai MA
Author Information
1. 贵州中医药大学第二临床医学院，贵阳 550002
- Keywords:
Arthritis, rheumatoid;
Osteoporosis;
Dyslipidemias;
Postmenopause
- From:
Chinese Journal of Rheumatology
2023;27(7):446-451
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To retrospectively analyze the correlation between blood lipoprotein levels and the risk of osteoporosis (OP) development in postmenopausal patients with RA and its influencing factors.Methods:Patients hospitalized with a definite diagnosis of RA from July 2017 to May 2020 were retrospectively collected and analyzed by bone mineral density (BMD) in subgroups, using correlation analysis, di-chotomous Logistic regression to quantify independent associations between laboratory test results and out-comes, and restrictive cubic spline (RCS) to fit the relationship of OP risk occurrence.Results:Six hundred and sixty-six eligible RA patients were included according to inclusion criteria, including 253 RA-OP and 413 RA-non-OP patients. After exclusion of relevant influencing factors by comparing demographic characteristics, a significant correlation was found between blood HDL-C ( r=-0.11, P=0.006) LDL-C ( r=0.12, P=0.003) levels and RA-OP( P<0.05), and dichotomous Logistic regression showed that as BMI ( OR(95% CI)=0.81(0.77, 0.86), P<0.001], calcium [ OR(95% CI)=0.24(0.10, 0.63), P<0.001], HDL-C[ OR(95% CI)=0.38(0.22, 0.66), P<0.001] increased, the risk of developing OP in RA patients decreased. In contrast, the risk of developing OP increased with increasing age [ OR(95% CI)=1.10(1.07, 1.21), P<0.001), disease duration [ OR(95% CI)=1.00(1.00, 1.00), P=0.020], and LDL-C[ OR(95% CI)=1.71(1.38, 2.12), P<0.001]. Conclusion:Blood HDL-C and LDL-C levels are significantly correlated with the development of RA-OP, and can be used as predictors of OP development and good indicators for disease monitoring in RA patients.
