Follow-up study on the effect of anti-hypertensive therapy on left ventricular myocardial work in elderly patients with hypertension
10.3760/cma.j.cn131148-20230307-00134
- VernacularTitle:降压治疗对老年高血压患者左室心肌做功影响的随访研究
- Author:
Xiaoyan KANG
1
;
Junyu LIU
;
Jiayu ZHANG
;
Chunsong KANG
;
Jiping XUE
Author Information
1. 山西白求恩医院（山西医学科学院同济山西医院） 山西医科大学第三医院超声科，太原 030032
- Keywords:
Ultrasonography;
Speckle tracking imaging;
Pressure-strain loop;
Hypertension;
Anti-hypertensive;
Elderly;
Myocardial work
- From:
Chinese Journal of Ultrasonography
2023;32(9):782-789
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of different blood pressure control levels on myocardial work by left ventricular pressure-strain loop (LVPSL) in elderly hypertensive patients.Methods:Retrospectively, 158 elderly patients with hypertension in Shanxi Bethune Hospital from January to June 2017 were randomly divided into standard anti-hypertensive group ( n=75) and intensive anti-hypertensive group ( n=83). Another 48 cases of age and sex matched elderly without cardiovascular and cerebrovascular diseases and other diseases affecting cardiac function were selected as control group. All patients with hypertension underwent echocardiography at baseline, 12 and 24 months after antihypertensive treatment. The parameters of myocardial work, including global work index (GWI), global constructive work (GCW), global wasted work (GWW) and global work efficiency (GWE), were obtained by LVPSL. The changes of myocardial work parameters were compared between the standard group and the intensive group after 12 and 24 months of antihypertensive treatment. Results:①At baseline, GWI, GCW, GWW of the standard group and the intensive group were significantly higher than those of the control group (all P<0.05). ②After 12 and 24 months of antihypertensive treatment, GWI, GCW and GWW in standard and intensive antihypertensive groups decreased continuously ( P<0.05). ③The GWI, GCW and GWW of the intensive antihypertensive group were lower than those of the standard antihypertensive group at 12 and 24 months after antihypertensive treatment ( P<0.05). ④After 12 months of antihypertensive treatment, the reductions of GWI, GCW and GWW in standard and intensive antihypertensive groups were greater than those in 24 and 12 months of antihypertensive treatment (all P<0.05), and the reductions of GWI, GCW and GWW in intensive antihypertensive group were greater than those in standard antihypertensive group (all P<0.05). Conclusions:Left ventricular systolic function decreases and myocardial work increases in elderly hypertensive patients. Left ventricular systolic function improves after antihypertensive treatment, and the improvement of intensive antihypertensive is more obvious than that of standard antihypertensive treatment.
