Role of sleep architecture in the assessment and recovery of conscious state in patients with consciousness disorders following traumatic brain injury: a review
10.3760/cma.j.cn501098-20231113-00312
- VernacularTitle:睡眠结构在创伤性脑损伤后意识障碍患者意识状态评估及恢复中作用的研究进展
- Author:
Nantu HU
1
;
Yan LI
;
Haibo DI
Author Information
1. 杭州师范大学国际植物状态和意识科学研究所，杭州 311121
- Keywords:
Craniocerebral trauma;
Consciousness disorders;
Sleep architecture
- From:
Chinese Journal of Trauma
2024;40(2):140-145
- CountryChina
- Language:Chinese
-
Abstract:
Consciousness disorders following traumatic brain injury (TBI) are alterations in consciousness due to damage to the brain parenchyma and/or brain vessels. As the number of TBI patients continues to increase, so does the number of patients with consciousness disorders following TBI. The patients′ quality of life was seriously affected due to a long course of illness and loss of most of independence. However, at present, the mechanisms of consciousness disorders in TBI are still unknown. The assessment of conscious state in patients with consciousness disorders following TBI mainly depends on scales, resulting in a high rate of misdiagnosis. Common interventions, including pharmacological interventions such as amantadine and zolpidem, as well as non-pharmacological interventions such as neuromodulation and sensory stimulation programs, fail to achieve extensive efficacy. Therefore, there is an urgent need for more accurate assessment indicators as well as effective therapeutic interventions. Various neurophysiological activities sustained by sleep are crucial for consciousness. Sleep regularity is likely to reflect the conscious state of patients with consciousness disorders following TBI. Sleep regularity is generally reflected through sleep architecture, including circadian rhythms and various sleep characteristics. Therefore, the authors reviewed the research progress in the application of sleep architecture in the assessment and recovery of conscious state in patients with consciousness disorders following TBI, so as to provide reference for its clinical application.
