Research progress in pathogenesis and treatment of post-traumatic stress disorder in patients with traumatic brain injury
10.3760/cma.j.cn501098-20230625-00363
- VernacularTitle:创伤性脑损伤患者应激障碍发病机制及治疗方法的研究进展
- Author:
Yichao YE
1
;
Yangu GUO
;
Hantong SHI
;
Xiaoxiang HOU
;
Danfeng ZHANG
;
Lijun HOU
Author Information
1. 海军军医大学第二附属医院神经外科，上海 200003
- Keywords:
Brain injuries, traumatic;
Stress disorders, post-traumatic;
Combined modality therapy;
Pathogenesis
- From:
Chinese Journal of Trauma
2023;39(10):947-953
- CountryChina
- Language:Chinese
-
Abstract:
Posttraumatic stress disorder (PTSD), the most common mental illness after patients suffer physically or emotionally from traumatic events, can cause persistently strong, painful and terrible avoidance symptoms, emotional and cognitive changes, causing psychologically strong stimulation and heavy burden to patients and even leading to some extreme behavioral reactions. Traumatic brain injury (TBI) is an important factor in the occurrence of PTSD, both of which shares many similar pathological overlaps, and may coexist and interact with each other. The hippocampus and amygdala play a central role in the pathogenesis of PTSD, but the specific cellular and molecular and neural circuit mechanisms are still unclear. About two-thirds of the patients still meet the diagnostic criteria for PTSD after psychotherapy. However, the current treatment methods are complicated and not unified, and patients treated with medications may have adverse drug reactions, poor treatment outcomes and recurrence. Therefore, it is of great significance to further clarify the occurrence and development of PTSD in TBI patients. The authors reviewed the research progress of the pathogenesis and treatment of PTSD in TBI patients, so as to provide reference for the related research and treatment of PTSD in TBI patients.
