Hemorrhagic shock-induced vascular endothelial glycocalyx damage: progress on mechanism of damage and preventive and therapeutic strategies
10.3760/cma.j.cn501098-20230522-00290
- VernacularTitle:失血性休克致血管内皮糖萼损伤的机制及防治措施研究进展
- Author:
Yufang ZHANG
1
;
Hongjie DUAN
;
Hailiang BAI
;
Ran SUN
;
Huiting YUN
;
Zheng ZHANG
Author Information
1. 山西医科大学基础医学院，太原 030001
- Keywords:
Shock, hemorrhagic;
Endothelium, vascular;
Endothelial glycocalyx
- From:
Chinese Journal of Trauma
2023;39(9):847-856
- CountryChina
- Language:Chinese
-
Abstract:
Hemorrhagic shock, a life-threatening organ hypoperfusion caused by rapid, massive blood loss, is the leading cause of traumatic death in peacetime and wartime. The vascular endothelial glycocalyx (vEG) plays an important role in maintaining microcirculatory homeostasis. Severe ischemia and hypoxia of hemorrhagic shock can damage the vEG, leading to endothelial dysfunction and exacerbated microcirculatory and organ impairments. Therefore, early prevention and treatment of vEG damage in hemorrhagic shock can improve microcirculation dysfunction, which is of paramount importance for therapeutic efficacies and outcomes. There have been many studies on the prevention and treatment of vEG damage in hemorrhagic shock, but none is based on the management of vEG damage. The authors reviewed the progress on the mechanism and preventive and therapeutic strategies of vEG damage caused by hemorrhagic shock, hoping to provide reference for the further research of hemorrhagic shock-induced vEG damage.
