Relationship between killer cell immunoglobulin-like receptor genes and immune reconstitution failure in human immunodeficiency virus infection/acquired immunodeficiency syndrome patients after anti-retroviral therapy
10.3760/cma.j.cn311365-20230116-00016
- VernacularTitle:杀伤细胞免疫球蛋白样受体基因与人类免疫缺陷病毒感染/艾滋病患者抗反转录病毒治疗后发生免疫重建不良的相关性
- Author:
Xinyin MEI
1
;
Xiaojie LAO
;
Lei JI
;
Xianli XU
;
Chunlan ZHANG
;
Bingyang LU
;
Maowei CHEN
Author Information
1. 广西医科大学公共卫生学院广西艾滋病防治研究重点实验室，南宁 530000
- Keywords:
HIV;
Anti-retroviral therapy;
Immune reconstitution failure;
Killer cell immunoglobulin-like receptor
- From:
Chinese Journal of Infectious Diseases
2023;41(9):582-587
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relationship between killer cell immunoglobulin-like receptor ( KIR) genes and immune reconstitution failure in human immunodeficiency virus infection/acquired immunodeficiency syndrome (HIV/AIDS) patients after anti-retroviral therapy (ART). Methods:HIV/AIDS patients receiving ART for ≥1 year who attended the AIDS outpatient clinics of Wuming Hospital of Guangxi Medical University and People′s Hospital of Mashan from May 2007 to December 2019 were included. Patients were divided into immune reconstitution failure group and full immune reconstitution group. Polymerase chain reaction with sequence specific primers (PCR-SSP) was used to detect KIR genotypes in all subjects, and the genotype frequency (PF) of 16 KIR genotypes was calculated. Statistical analysis was conducted using chi-square test. Multivariate logistic regression was used to analyze the relationship between KIR genotypes and immune reconstitution failure.Results:There were 102 patients with HIV/AIDS, including 44 immunological non-responders and 58 immunological responders. The PF of KIR2 DL5 in immune reconstitution failure group was 59.09%(26/44), which was higher than 36.21%(21/58) in full immune reconstitution group, and the difference was statistically significant ( χ2=5.27, P=0.022). Multivariate logistics regression analysis showed that KIR2 DL5 was associated with immune reconstitution failure when adjusted for age and baseline CD4 + T cell count. Positive expression of KIR2 DL5 may be a risk factor for immune reconstitution failure (adjusted odds ratio (a OR)=2.431, 95% confidence interval 1.012 to 5.844, P=0.047). Conclusions:Positive expression of KIR2 DL5 may be related to immune reconstitution failure in HIV/AIDS patients after ART.
