Research Progress in the Mechanism of Astragaloside Ⅳ Against Myocardial Injury
10.19879/j.cnki.1005-5304.202304016
- VernacularTitle:黄芪甲苷抗心肌损伤作用机制研究进展
- Author:
Xuyong WANG
1
,
2
;
Xinke ZHAO
;
Hugang JIANG
;
Chunling WANG
;
Xiaogang ZHANG
;
Yingdong LI
Author Information
1. 甘肃中医药大学,甘肃 兰州 730000
2. 甘肃省中医药防治慢性疾病重点实验室,甘肃 兰州 730000
- Keywords:
astragaloside Ⅳ;
myocardial injury;
mechanism;
review
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(4):187-191
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial injury is a pathological change of myocardium caused by many factors,which can lead to the decline of cardiac function and the occurrence of cardiovascular events.Astragaloside Ⅳ is one of the main pharmacological components in Astragali Radix,which plays an anti-myocardial injury role by regulating various signaling pathways.This article reviewed the anti-myocardial injury mechanism of astragaloside Ⅳ from five aspects:inhibition of oxidative stress,inhibition of apoptosis,anti-myocardial fibrosis,improvement of myocardial energy metabolism and inhibition of myocardium inflammation,in order to provide reference for the mechanism research and clinical application of astragaloside Ⅳ in the prevention and treatment of myocardial injury.
