Meta-analysis on Xixian Tongshuan Preparation Combined with Conventional Western Medicine in the Treatment of Acute Ischemic Stroke
10.19879/j.cnki.1005-5304.202206513
- VernacularTitle:豨莶通栓制剂联合西医常规疗法治疗急性缺血性脑卒中Meta分析
- Author:
Yishan CHEN
1
,
2
;
Tianyuan WANG
;
Jing HU
;
Huina ZHANG
;
Hong WANG
;
Qian LIU
;
Bo LI
Author Information
1. 首都医科大学附属北京中医医院,北京市中医药研究所,北京中医药循证医学中心,北京 100010
2. 北京中医医院怀柔医院,北京 101400
- Keywords:
Xixian Tongshuan Capsules/Pills;
acute ischemic stroke;
randomized controlled trial;
Meta-analysis;
efficacy evaluation
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(4):44-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the efficacy of Xixian Tongshuan Capsules/Pills in the treatment of acute ischemic stroke(AIS).Methods Literature about Xixian Tongshuan Preparation combined with conventional Western medicine for the treatment of AIS was retrieved from CNKI,SinoMed,VIP,Wanfang Data,PubMed,Medline,Embase,Cochrane Library and Web of Science from establishment of the databases to February 28,2023.Meta-analysis was conducted for the studies that could be quantitatively analyzed.The effective rate and response indicators were combined.Results A total of 7 articles were included for Meta-analysis.Results showed that there was statistical difference in the effective rate(RR=0.34,95%CI[0.23,0.51],P<0.01),NIHSS score(MD=-2.90,95%CI[-3.74,-2.06],P<0.01),BI score(MD=-10.08,95%CI[-13.47,-6.68],P<0.01),FIB(MD=-1.18,95%CI[-1.59,-0.77],P<0.01)of Xixian Tongshuan Preparation combined with conventional Western medicine for the treatment of AIS.There was no statistical difference in IL-6(MD=-15.4,95%CI[-33.3,2.49],P=0.09).There was no statistical difference in the effects of different dosage forms and treatment courses on the effective rate and NIHSS score.Conclusion The combination of Xixian Tongshuan Capsules/Pills could better improve the NIHSS and BI scores of patients with AIS,recovery the neurological function,and reduce the risk of blood hypercoagulability by reducing FIB content,with good safety.
