Exploration on the Application of Partially Nested Design in Effectiveness Assessment of Different Treatment for the Same Disease in TCM and Its Methodology
10.19879/j.cnki.1005-5304.202302491
- VernacularTitle:部分嵌套式设计在中医药"同病异治"疗效评价中的应用及方法学探索
- Author:
Shuo FENG
1
,
2
;
Jizheng MA
;
Yufeng GUO
;
Jian CAO
;
Jing HU
;
Xing LIAO
Author Information
1. 中国中医科学院广安门医院(南区),北京 102618
2. 北京中医药循证医学中心,北京 100010
- Keywords:
partially nested design;
different treatments for the same disease;
evidence-based medicine;
efficacy evaluation;
methodology
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(4):26-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To introduce a partially nested design based on the characteristics of TCM in treating the same disease with different treatments and syndrome differentiation and treatment.Methods Partially nested design was used for standardized treatment of complex interventions.The TCM group was divided into multiple subsets according to"syndrome type-treatment method-prescription"(with nested structure),while the control group was treated with standardized Western medicine(without nested structure);taking a case study of"different treatments for the same disease"data for ulcerative colitis,this design type was applied and analyzed using a multi-level model.Results The partially nested design was consistent with the feature of TCM of"different treatments for the same disease"and met the methodological requirements for evidence-based evaluation.Multilevel models allowed analyses with this type of data.Conclusion The use of partially nested design enables the evaluation of the comprehensive effectiveness of"different treatments for the same disease",which can provide a methodological reference for the assessment of clinical effectiveness of TCM.
