Discussion on the Effects of Mitochondrial Homeostasis in Heart Failure Based on"Yin-yang Theory"
10.19879/j.cnki.1005-5304.202301310
- VernacularTitle:基于"阴阳理论"探讨线粒体稳态在心力衰竭中的作用
- Author:
Chengxin LIU
1
;
Jiaming WEI
;
Ziyan WANG
;
Min SHI
;
Hui YUAN
;
Ya LI
;
Zhihua GUO
Author Information
1. 湖南中医药大学第一中医临床学院,湖南 长沙 410208
- Keywords:
mitochondria;
mitophagy;
mitochondrial dynamics;
mitochondrial homeostasis;
TCM;
heart failure
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(4):10-15
- CountryChina
- Language:Chinese
-
Abstract:
Heart failure is a group of complex clinical syndromes in the middle and late stages of cardiovascular diseases.Mitochondrial homeostasis imbalance is one of the pathological mechanisms in the occurrence and development of heart failure.This article revolved around the"yin-yang theory"in TCM and explained the pathological mechanism of heart failure through mitochondrial homeostasis.Heart failure is the syndrome of deficiency in nature and excess in superficiality fundamental.Its basic pathogenesis is"yang deficiency and yin excess".Based on the deficiency of heart yang qi and the stagnation of yin pathogens,the combination of deficiency and excess runs through the entire disease.Mitochondrial homeostasis imbalance is a manifestation of yin-yang imbalance at the cellular micro level,mainly manifested as inhibition of mitochondrial biosynthesis,mitochondrial dynamics imbalance,mitophagy disorder,etc.,which affects mitochondrial structure and function and leads to abnormal myocardial energy metabolism.Therefore,based on the"yin-yang theory",the basic treatment method is to"tonify deficiency and damage excess"to regulate mitochondrial biosynthesis,mitochondrial dynamics,and mitophagy,thereby maintaining mitochondrial homeostasis and improving myocardial energy metabolism,which is of great significance for the prevention and treatment of heart failure.
