Research Progress in the Treatment of Ulcerative Colitis with Sishen Pills
10.19879/j.cnki.1005-5304.202302459
- VernacularTitle:四神丸治疗溃疡性结肠炎研究进展
- Author:
Kaiyang LI
1
;
Mei YANG
;
Qi ZHAO
;
Jing HUANG
;
Xiaoyuan LIN
;
Jiemin LIU
;
Zhenfan GUO
;
Hui SHI
;
Yueyue YANG
Author Information
1. 贵州中医药大学,贵州 贵阳 550002
- Keywords:
Sishen Pills;
spleen-kidney yang deficiency;
ulcerative colitis;
mechanism;
TCM treatment;
review
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(3):180-185
- CountryChina
- Language:Chinese
-
Abstract:
Sishen Pills is a classic prescription for the treatment of spleen and kidney diarrhea,which has the effect of warming the kidney and the spleen,astringent intestine and antidiarrheal.In modern clinical application,the modified prescriptions based on Sishen Pills,combined with other treatments of TCM and integrated traditional Chinese and Western medicine are often used to treat ulcerative colitis with spleen-kidney yang deficiency syndrome,and the curative effect is remarkable.Experimental pharmacological studies have shown that Sishen Pills may achieve the purpose of ulcerative colitis by regulating the expression of related signaling pathway proteins,regulating inflammatory factors,inhibiting inflammatory response,regulating autophagy,regulating intestinal flora,improving intestinal mucosal permeability,repairing intestinal mucosal barrier,regulating cellular energy metabolism,anti-oxidative stress,regulating cellular immune function,etc.In this article,the research status of Sishen Pills in the treatment of ulcerative colitis was sorted out and summarized,in order to provide reference for further study of its mechanism and clinical application.
