Systematic Review and Sequential Analysis of Efficacy and Safety of Baogong Zhixue Granules for the Treatment of Abnormal Uterine Bleeding due to Ovulation Disorder
10.19879/j.cnki.1005-5304.202301278
- VernacularTitle:葆宫止血颗粒治疗排卵障碍性异常子宫出血疗效及安全性的系统评价和序贯分析
- Author:
Xinyin HU
1
;
Xuhan SU
;
Haoye PENG
;
Zuolin TAN
;
Yunqing LI
;
Yuhua HUANG
Author Information
1. 北京中医药大学,北京 100029
- Keywords:
Baogong Zhixue Granules;
abnormal uterine bleeding due to ovulation disorder;
metrorrhagia;
Meta-analysis;
trail sequential analysis
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(3):48-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate and sequentially analyze the clinical efficacy and safety of Baogong Zhixue Granules for the treatment of abnormal uterine bleeding due to ovulation disorder.Methods The randomized controlled trials(RCTs)of Baogong Zhixue Granules for the treatment of abnormal uterine bleeding due to ovulation disorder were retrieved from the databases of CNKI,Wanfang Data,VIP,China Biology Medicine,PubMed,Embase,and Cochrane Library from the establishment of the databases to January 5th,2023.Literature screening and data extraction were conducted according to Cochrane Handbook for Systematic Reviews of Interventions,and Meta-analysis was performed by RevMan 5.4.Results Totally 15 articles were included,involving 1 425 patients.Meta-analysis results showed that Baogong Zhixue Granules could effectively improve the clinical efficacy of abnormal uterine bleeding due to ovulatory disorder(RR=1.17,95%CI[1.13,1.23],P<0.000 01),shorten hemostasis time[bleeding control time(MD=-6.35,95%CI[-8.89,-3.81],P<0.000 01),complete hemostasis time(MD=-12.56,95%CI[-16.22,-8.89],P<0.000 01)],reduce endometrial thickness(MD=-1.26,95%CI[-1.71,-0.80],P<0.000 01),reduce hemoglobin loss(MD=13.35,95%CI[11.41,15.29],P<0.000 01),improve the score of uterine bleeding(MD=-2.22,95%CI[-2.43,-2.01],P<0.000 01),and reduce the recurrence of disease(RR=0.37,95%CI[0.19,0.72],P=0.004).There was no statistical significance between the test group and the control group in terms of adverse reactions(P=0.82).The trial sequential analysis of the total efficiency was carried out,and the cumulative included research passed the traditional threshold and trail sequential analysis threshold.Conclusion Baogong Zhixue Granules have a certain clinical efficacy in the treatment of abnormal uterine bleeding due to ovulation disorder,but there may be publication bias in the study,and higher quality clinical RCTs need to be carried out.
