Research Progress of TCM in Improving Ulcerative Colitis Based on PI3K/AKT Signaling Pathway

VernacularTitle:基于PI3K/AKT信号通路中医药改善溃疡性结肠炎机制研究进展
Author: Yuping SHU ¹ ; Danqi YU ; Yue RONG ; Hongwu TAO ; Yuedong LIU
Author Information

1. 辽宁中医药大学,辽宁沈阳 110847
Keywords: TCM; PI3K/AKT signaling pathway; ulcerative colitis; review
From: Chinese Journal of Information on Traditional Chinese Medicine 2024;31(2):191-196
CountryChina
Language:Chinese
Abstract: Ulcerative colitis(UC)is a common disease of the digestive system.Phosphatidylinositol-3-kinase(PI3K)/synuclein/threonine kinase(AKT)is closely related to cell survival,apoptosis,inflammation and other biological processes,and the expression levels of PI3K and AKT significantly increase during the course of UC,with accelerated apoptosis,improved inflammation,and damaged intestinal mucosal barrier function.In recent years,a large number of basic and clinical trials have been conducted on PI3K/AKT signaling pathway in TCM,and the results indicate that PI3K/AKT signaling pathway is expected to be an important potential target for UC treatment.This article analyzed the mechanism of the regulation of PI3K/AKT signaling pathway in TCM from monomer,extract,compound and acupuncture,and suggested that the regulation of this signaling pathway is of great significance for the prevention and treatment of UC,and provide reference for drug development.