Exploration on Scientific Connotation of Pathogenesis Theory of Gastric Cancer"Spleen Deficiency and Stasis Toxin"Based on the Reprogramming of Glucose Metabolism in Tumor-associated Macrophages
10.19879/j.cnki.1005-5304.202307044
- VernacularTitle:基于肿瘤相关巨噬细胞糖代谢重编程探讨胃癌"脾虚瘀毒"病机理论科学内涵
- Author:
Peipei YANG
1
,
2
;
Wenjie HUANG
;
Qiurong LI
;
Liuxiang WANG
;
Xiaotao NIU
;
Peng SHU
Author Information
1. 南京中医药大学附属医院,江苏 南京 210029
2. 南京中医药大学,江苏 南京 210029
- Keywords:
spleen deficiency and stasis toxin;
tumor microenvironment;
tumor-associated macrophages;
glycolytic reprogramming;
gastric cancer;
TCM
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(2):6-10
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis theory of"spleen deficiency and stasis toxin"in gastric cancer holds that spleen is the source of generation and transformation of qi and blood,that spleen deficiency is the internal basis of disease and throughout the disease.Stasis toxin is based on spleen deficiency,which is the fundamental pathogenesis of gastric cancer.In the pathological process of gastric cancer,a variety of metabolic substances in tumor cells and tumor microenvironment,mainly glucose metabolic reprogramming,undergo metabolic changes to reconstruct the phenotype and function of tumor-related macrophages,which is consistent with the pathogenesis theory of"spleen deficiency and stasis toxin".Therefore,this article focused on the reprogramming of glucose metabolism in tumor microenvironment to drive the phenotypic remodeling of tumor-related macrophages,explored the scientific connotation of the pathogenesis theory of"spleen deficiency and stasis toxin"of gastric cancer,and provided references for the theoretical and clinical research on the treatment of gastric cancer by TCM.
