Research Progress in the Mechanism of TCM for Regulating JAK/STAT Signaling Pathway in Intervention of Myocardial Ischemia-reperfusion Injury

VernacularTitle:中药调控JAK/STAT信号通路干预心肌缺血再灌注损伤作用机制研究进展
Author: Xiaobin ZHAO ¹ ; Xinqiang WANG ; Hugang JIANG ; Jinyan HAN ; Xiaogang ZHANG ; Yingdong LI ; Xinke ZHAO
Author Information

1. 甘肃中医药大学,甘肃兰州 730000
Keywords: TCM; JAK/STAT signaling pathway; myocardial ischemia-reperfusion injury; review
From: Chinese Journal of Information on Traditional Chinese Medicine 2024;31(1):191-196
CountryChina
Language:Chinese
Abstract: Acute myocardial infarction(AMI)is a common cardiovascular emergency in clinic.Early reperfusion is a typical and effective method for the treatment of AMI.However,the recovery of blood supply after reperfusion therapy will accelerate the damage of ischemic myocardium and cause myocardial ischemia-reperfusion injury(MI/RI).In recent years,studies have found that TCM has the unique advantages of multi-component,multi-channel and multi-target in the intervention of MI/RI.Janus tyrosine kinase/signal transducer and activator of transcription(JAK/STAT)signaling pathway is closely related to MI/RI,which can reduce MI/RI process by regulating inflammation,oxidative stress,cell proliferation,differentiation and apoptosis.This article reviewed the mechanism of JAK/STAT signaling pathway in MI/RI and the research of TCM targeting this pathway,in order to provide references for the prevention and treatment of MI/RI and further drug development.