The mechanism of immune thrombosis and related research progress

VernacularTitle:免疫血栓形成机制及相关研究进展
Author: Jiawei JIANG ^{1
,

2} ; Rui YANG ; Jiating BAO ; Huihong ZHANG ; Hongmei GAO
Author Information

1. 天津市第一中心医院重症医学科,天津 300192
2. 国家卫生健康委危重病急救医学重点研究室,天津 300192
Keywords: Immunothrombosis; Neutrophil extracellular trapping network; Platelet
From: Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care 2023;30(6):749-754
CountryChina
Language:Chinese
Abstract: Immunothrombosis refers to the innate immune response caused by thrombosis in blood vessels(especially microvessels).Immunothrombosis is related to immune cells and specific thrombosis related molecules,producing intravascular scaffolds that promote pathogen recognition,inhibition,and destruction,thereby protecting the integrity of the host.However,abnormal or uncontrolled activation of immunothrombosis may be harmful to the host and serve as the foundation for various infectious and inflammatory related thrombotic diseases.Therefore,understanding the potential mechanisms of immunothrombosis plays a decisive role in developing more effective therapies for thrombosis treatment and prevention.This review provides an overview of the mechanisms of immunothrombosis in order to understand new treatment strategies for reducing the risk of immunothrombosis.