Research progress of iron homeostasis and ferroptosis in acute kidney injury
10.3969/j.issn.1008-9691.2023.05.023
- VernacularTitle:铁稳态和铁死亡与急性肾损伤的研究进展
- Author:
Ting LIAO
1
,
2
;
Jiangquan YU
;
Ruiqiang ZHENG
Author Information
1. 扬州大学医学院,江苏扬州 225001
2. 扬州大学临床医学院/苏北人民医院重症医学科,江苏扬州 225001
- Keywords:
Acute kidney injury;
Iron homeostasis;
Ferroptosis;
Lipid peroxidation
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2023;30(5):628-631
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a non-apoptotic form of cell death newly discovered in 2012.It is characterized by a lethal accumulation of iron-dependent reactive oxygen species and lipid hydroperoxides,resulting in mitochondrial morphological changes and phospholipid peroxidation damage of cell membrane.As a strong oxidizing agent in biological systems,iron overloaded,can directly cause acute kidney injury(AKI)through oxidative damage.Iron homeostasis disturbance and ferroptosis are directly involved in AKI caused by ischemia-reperfusion,drugs and rhabdomyolysis,etc.This article reviews the relevant evidence and the important mechanism of iron homeostasis and ferroptosis in AKI,and provides new ideas and new targets for further research and treatment of AKI.
