Study on the treatment of sepsis-induced cardiomyopathy with traditional Chinese medicine based on mitochondrial dysfunction
10.3969/j.issn.1008-9691.2023.05.001
- VernacularTitle:基于线粒体功能障碍探讨中医药治疗脓毒性心肌病的研究思路
- Author:
Zheng WANG
1
,
2
;
Yu WANG
;
Pei JIN
;
Yanjun WANG
;
Bing JIANG
;
Zheng ZHANG
Author Information
1. 甘肃中医药大学,甘肃兰州 730000
2. 甘肃中医药大学附属医院重症医学科,甘肃兰州 730000
- Keywords:
Sepsis-induced cardiomyopathy;
Mitochondrial dysfunction;
Traditional Chinese medicine
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2023;30(5):513-516
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis-induced cardiomyopathy(SIC)is an important cause of poor prognosis in patients with sepsis.As a key organelle for energy synthesis,mitochondrial damage leading to myocardial energy metabolism disorders has become the core pathophysiological mechanism of SIC.Traditional Chinese medicine treatment is of great significance for improving cardiac function and improving therapeutic effects in patients with sepsis.This article reviews the pathological and physiological mechanisms of mitochondrial dysfunction in myocardial cells during sepsis from the perspectives of mitochondrial dynamics,antioxidant stress damage,mitochondrial biosynthesis,and mitophagy,as well as the protective mechanisms of traditional Chinese medicine targeting the improvement of mitochondrial dynamics,mitochondrial biosynthesis,mitophagy,and mitochondrial antioxidant stress damage to alleviate myocardial injury.Explore the pharmacodynamic material basis of Traditional Chinese medicine for treating SIC,and expand new ideas for the treatment of SIC with traditional Chinese medicine.
