Research progress on factors influencing the therapeutic effect of gemtuzumab ozo-gamicin for acute myeloid leukemia

VernacularTitle:吉妥珠单抗治疗急性髓系白血病的疗效影响因素分析
Author: Guangqiang MENG ¹ ; Saran FENG ; Yan WANG
Author Information

1. 山东第一医科大学第一附属医院(山东省千佛山医院)血液内科 (济南市 250014)
Keywords: acute myeloid leukemia(AML); gemtuzumab ozogamicin(GO); treatment; affecting factors
From: Chinese Journal of Clinical Oncology 2024;51(1):45-48
CountryChina
Language:Chinese
Abstract: Acute myeloid leukemia(AML)is a heterogeneous myeloid malignancy.Currently,chemotherapy combined with hematopoietic stem cell transplantation is the primary treatment option;however,over-all prognosis remains poor.Gemtuzumab ozogamicin(GO)is a hu-manized CD33 monoclonal antibody conjugated with calicheamicins.It is primarily used to treat CD33-positive AML.Although studies have found that GO can improve the prognosis of patients with CD33-positive AML,some patients with AML do not benefit from it.Recent stud-ies have found that the effect of GO on AML is primarily associated with the expression of CD33 and its single nucleotide polymorphism(SNP),ATP-binding cassette subfamily B member 1(ABCB1)gene and SNP,as well as specific molecular biology and cytogenetics.This paper reviews the research progress on the factors influencing efficacy of GO for treating AML.