Research progress of organoid models in bladder cancer
10.12354/j.issn.1000-8179.2024.20240005
- VernacularTitle:类器官模型在膀胱癌中的研究进展
- Author:
Wei HE
1
;
Yidie YING
;
Maoyu WANG
;
Shuxiong ZENG
;
Chuanliang XU
Author Information
1. 海军军医大学第一附属医院泌尿外科(上海市 200433)
- Keywords:
bladder cancer;
organoids;
personalized diagnosis and treatment;
drug sensitivity
- From:
Chinese Journal of Clinical Oncology
2024;51(1):41-44
- CountryChina
- Language:Chinese
-
Abstract:
Organoids are novel in vitro models that can effectively simulate the complexities of tumor microenvironments.Compared to tra-ditional preclinical models,organoids retain most of the histological and molecular properties of the primary tumor;therefore,they are more useful for studying tumor heterogeneity,underlying functional pathways,and immune microenvironments as well as for research on biomarker discovery,drug screening,and individual chemotherapy.Furthermore,current limitations,challenges such as low modeling suc-cess rates,high costs,and lack of standardization are expected to be overcome by continued innovations in bioengineering technologies and interdisciplinary integration.This article reviews the advantages,establishment processes,and prospects and challenges associated with the clinical application of organoids in bladder cancer.
