Clinical research progress on lymph node metastasis in gastric mixed adenoneuroen-docrine carcinoma
10.12354/j.issn.1000-8179.2023.20231147
- VernacularTitle:胃混合性腺神经内分泌癌淋巴结转移的临床研究进展
- Author:
Kai ZHOU
1
;
Anqiang WANG
;
Yan WU
;
Zhongwu LI
;
Zhaode BU
Author Information
1. 北京大学肿瘤医院暨北京市肿瘤防治研究所胃肠肿瘤中心,恶性肿瘤发病机制及转化研究教育部重点实验室(北京市 100142)
- Keywords:
gastric mixed adenoneuroendocrine carcinoma(G-MANEC);
lymph node metastasis pattern;
hematogenous and distant metastasis
- From:
Chinese Journal of Clinical Oncology
2023;50(24):1275-1279
- CountryChina
- Language:Chinese
-
Abstract:
Gastric mixed adenoneuroendocrine carcinomas(G-MANEC)are an infrequent variant of gastrointestinal tumors.Despite their relatively low occurrence,there has been a noticeable upward trend.G-MANEC exhibit a highly invasive nature,frequently leading to lymph-atic and distant metastases,which ultimately result in unfavorable prognosis.Consequently,this condition has garnered considerable in-terest among researchers.G-MANEC are characterized by the presence of adenocarcinoma and neuroendocrine carcinoma components,with each component comprising at least 30%of the tumor.In recent years,a growing body of knowledge regarding G-MANEC has led to a more comprehensive research approach towards this type of carcinoma.Nevertheless,there has been a notable deficiency to date in the ex-amination of lymph node metastatic aspects of G-MANEC,which poses several pressing challenges that demand immediate resolutions.This review aims to systematically analyze previous case reports and studies on mixed neuroendocrine-non-neuroendocrine neoplasms(MiNEN)while incorporating research on gastric cancer.This study focuses on various aspects of G-MANEC,including the epidemiology,biological ori-gin,diagnosis,patterns of lymph node metastasis,relationship with hematogenous metastasis,association between lymphatic and distant metastases,and treatment.The objective is to offer guidance for future research endeavors concerning G-MANEC.
