Effect of stroke volume variation-guided fluid therapy on renal function in older pa-tients
10.12354/j.issn.1000-8179.2023.20231062
- VernacularTitle:老年患者术中每搏变异度指导液体治疗对肾功能的影响
- Author:
Tao SUN
1
;
Tao WANG
;
Huan LIU
;
Yue GAO
;
Libiao LI
Author Information
1. 内蒙古医科大学附属医院麻醉科(呼和浩特市 010000)
- Keywords:
stroke volume variation(SVV);
appropriate fluid therapy;
epidural and general anesthesia;
acute kidney injury(AKI);
older patients
- From:
Chinese Journal of Clinical Oncology
2023;50(24):1259-1264
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the renoprotective benefits of stroke volume variation(SVV)-guided fluid therapy in older patients under-going laparoscopic colorectal cancer resection with combined administration of epidural and general anesthesia.Methods:A total of 100 older patients underwent laparoscopic colorectal cancer resection with combined administration of epidural and general anesthesia at The Affiliated Hospital of Inner Mongolia Medical University.Participants were randomly allocated into the control(group C)and experimental groups(group S).Each group consisted of an equal distribution of 50 patients.Group C received routine rehydration,while group S under-went SVV-guided fluid rehydration.To compare the two groups,the levels of serum creatinine(Scr),blood urea nitrogen(BUN),neutrophil gelatinase-associated lipocalin protein(NGAL),and kidney injury molecule-1(KIM-1)were analyzed before and after surgery.Results:NGAL concentrations were significantly reduced in group S compared with those in group C at 2 and 24h after surgery(P=0.033,P=0.014).KIM-1 levels were significantly lower in group S than in group C 24h after surgery(P=0.012).Furthermore,Scr levels were significantly lower in group S than in group C 1 day after surgery(P=0.049).The incidence of postoperative acute kidney injury(AKI)was significantly higher in group C than in group S(P=0.027).Conclusions:In older patients undergoing laparoscopic radical resection of colorectal cancer,the imple-mentation of SVV-guided fluid therapy can improve postoperative plasma markers of renal injury and reduce the incidence of postoperative AKI,thereby protecting renal function.
