Efficacy and safety analyses of R-BAP in combination with BTK inhibitors in newly dia-gnosed patients with mantle cell lymphoma
10.12354/j.issn.1000-8179.2023.20231336
- VernacularTitle:R-BAP联合BTK抑制剂方案对初治套细胞淋巴瘤患者的疗效和安全性分析
- Author:
Wenqi LI
1
;
Ziqi CHEN
;
Jinmiao SUN
;
Yu CHANG
;
Xiyang LIU
;
Mingzhi ZHANG
;
Lei ZHANG
Author Information
1. 郑州大学第一附属医院肿瘤科,河南省淋巴瘤诊疗中心(郑州市 450052)
- Keywords:
mantle cell lymphoma(MCL);
chemotherapy;
BTK inhibitor;
efficacy;
safety
- From:
Chinese Journal of Clinical Oncology
2023;50(24):1248-1253
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To improve the therapeutic regimen for mantle cell lymphoma,we investigated the efficacy and safety of adding a BTK inhibitor to a regimen including rituximab,bendamustine,cytarabine,and prednisone to treat patients with mantle cell lymphoma(MCL).Methods:Twenty-six patients newly diagnosed with MCL who were admitted to The First Affiliated Hospital of Zhengzhou University from March 2021 to November 2023 were treated with a regimen of rituximab,bendamustine,cytarabine and prednisone combined with a BTK inhibitor,and the efficacy and adverse effects of this regiment were retrospectively analyzed.Results:The median age of the 26 newly dia-gnosed MCL patients was 59(41-72)years.The cohort included 22 males and 4 females,and the median follow-up time was 12(3-28)months.The overall response rate(ORR)was 92.3%and the complete response rate(CRR)was 88.5%.Median progression-free survival(PFS)and median overall survival(OS)endpoints were not achieved,with a 1-year PFS rate of 81.25%and a 1-year OS rate of 92.3%.A bet-ter PFS was achieved in the low mantle cell lymphoma International Prognostic Index(MIPI)score(0-3 points)group than in the high MIPI score(4-11 points)group(P=0.020).PFS was better in the group without B symptoms than in the group with B symptoms(P=0.002).PFS was better in the classical group than in the pleomorphic-blastoid subtype group(P=0.009).The main adverse effects were lymphopenia and thrombocytopenia.No treatment-related serious adverse events were observed during the follow-up period.Conclusions:The regimen of rituximab,bendamustine,cytarabine,and prednisone in combination with BTK inhibitors is safe and effective for the treatment of newly dia-gnosed patients with MCL.
