Research progress on the role of tumor-associated high endothelial venules in anti-tu-mor therapy
10.12354/j.issn.1000-8179.2023.20231039
- VernacularTitle:肿瘤相关性高内皮微静脉在肿瘤治疗中角色的研究进展
- Author:
Yan LIU
1
;
Chuangui ZHANG
Author Information
1. 天津医科大学肿瘤医院特需病房,国家恶性肿瘤临床医学研究中心,天津市"肿瘤防治"重点实验室,天津市恶性肿瘤临床医学研究中心(天津市 300060)
- Keywords:
tertiary lymphoid structures;
high endothelial venules(HEVs);
tumor-associated high endothelial venules(TA-HEVs);
anti-tumor therapy
- From:
Chinese Journal of Clinical Oncology
2023;50(23):1231-1235
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumor blood vessels,with phenotypes that are similar to high endothelial venules(HEVs)in secondary lymphoid or-gans(SLO),are known as tumor-associated high endothelial venules(TA-HEVs).The formation mechanism of TA-HEVs is similar to that of HEVs.Moreover,TA-HEVs play an important role in promoting the infiltration of lymphocytes into tumor tissues.With ongoing research,the positive effect of TA-HEVs in the context of radiotherapy,chemotherapy,immunotherapy,and antiangiogenic therapy is being elucidated.The clinical value is gradually becoming prominent,and the mechanisms and pathways involved with TA-HEVs are still under investigation.
