Advances in hypoxic tumor microenvironment-targeting mechanisms in multiple myel-oma treatment
10.12354/j.issn.1000-8179.2023.20231243
- VernacularTitle:靶向缺氧肿瘤微环境在多发性骨髓瘤治疗中的机制研究进展
- Author:
Yixin WEI
1
;
Liansheng ZHANG
;
Xiaosha LI
;
Lijuan LI
Author Information
1. 兰州大学第二医院血液科(兰州市 730030)
- Keywords:
multiple myeloma(MM);
tumor microenvironment(TME);
hypoxia inducible factor-1(HIF-1);
antitumor therapy;
HIF inhibitor
- From:
Chinese Journal of Clinical Oncology
2023;50(23):1227-1230
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma(MM)is a highly heterogeneous and refractory plasma cell tumor.It is similar to most solid tumors in the hyp-oxic tumor microenvironment(TME)it is exposed to,promoting hypoxia inducible factor-1(HIF-1)activation and related transcription factors of the corresponding downstream signaling pathways,affecting tumor angiogenesis,myeloma cell dissemination and metastasis,anti-tumor immunity,tumor immune escape promotion as well as altering the cellular energy metabolism and participating in therapeutic resistance in-duction.In this study,based on the above-described mechanisms,we aim at reviewing the current research status of hypoxic microenviron-ment-targeting therapies in MM treatment,focusing on the direct inhibition of HIF factors or signaling pathway targeting;metabolism im-provement and oxygenation increase;effective tumor immunity restoration by targeting immune checkpoints;anti-angiogenesis.Precise hypoxia targeting combined with standardized therapy offers a promising strategy and research hotspot in MM therapy.
