Clinicopathological characteristics analysis of 20 cases of head and neck spindle cell squamous cell carcinoma
10.12354/j.issn.1000-8179.2023.20230923
- VernacularTitle:头颈部梭形细胞鳞状细胞癌20例临床病理特征分析
- Author:
Ming HAN
1
;
Mengwei XU
;
Li SHI
;
Yingmei WANG
;
Yixiong LIU
;
Wanni XU
;
Yuqiao XU
Author Information
1. 空军军医大学第一附属医院病理科(西安市 710032)
- Keywords:
head and neck;
squamous cell carcinoma;
spindle cell squamous cell carcinoma(SCSCC);
clinicopathologic features;
immun-ohistochemistry
- From:
Chinese Journal of Clinical Oncology
2023;50(22):1147-1152
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinicopathological features,immunophenotype,and prognosis of head and neck spindle cell squamous cell carcinoma(SCSCC)to improve the understanding and diagnosis of this tumor.Methods:Clinicopathological data collected from January 2012 to December 2022 at the First Affiliated Hospital,Air Force Military Medical University from 20 patients with head and neck SCSCC were retrospectively reviewed for histological morphology and immunophenotype.In situ and fluorescence in situ hybridization were performed to detect EBV-encoded ribonucleic acid(EBER)status and MDM2 gene amplification,respectively.Results:The median age among the 20 SCSCC cases was 67 years with a male-to-female ratio of 4∶1.Tumor locations were laryngeal(35.0%)and sinonasal(30.0%).SCSCC presented as polypoid or exogenous growths(61.5%),often with surface ulceration(90.0%).Histologically,sarcomatoid growth pat-terns were exhibited in 75.0%of the patients(n=15),while the remainder showed granular tissue-like or angiosarcomatoid patterns.Most tumors(65.0%)displayed components of conventional squamous cell carcinomas,with a predominant occurrence of high to moderate dif-ferentiation(91.7%).In terms of immunohistochemistry,AE1/AE3 was expressed in 83.3%(15/18)of cases,while p63 and p40 expression rates were 62.5%and 66.7%,respectively.All cases were negative for EBER.The Ki-67 proliferation index ranged 10%-70%.Overall,33.3%(1/3)of the cases showed MDM2 gene amplification.Among these,the median follow-up time for 18 patients was 18.3 months(range:1-92 months),with 6 survivors and 12 deaths.Conclusions:Head and neck SCSCC is more prevalent among elderly male smokers,predominantly exhibits a polypoid growth pattern,and does not display human papillomavirus or Epstein-Barr virus infection.Diagnosis requires a compre-hensive evaluation of clinical and pathological features and immunophenotype.Surgical resection is the primary treatment method.
