Clinical and pathological characteristics and prognostic analysis of gastric neuroendo-crine carcinoma
10.12354/j.issn.1000-8179.2023.20230946
- VernacularTitle:胃神经内分泌癌的临床病理特征及预后分析
- Author:
Fengjin SHANG
1
,
2
;
Sheng TAN
;
Weipeng WU
;
Jian JIAO
;
Lulu LI
;
Haoran ZHANG
;
Zhiguo TONG
;
Changhong LIAN
Author Information
1. 长治医学院附属和平医院胃肠外科 山西省长治市 046000
2. 长治医学院第一临床学院
- Keywords:
stomach;
neuroendocrine neoplasms(NEN);
adenocarcinoma;
pathological characteristics;
prognostic analysis
- From:
Chinese Journal of Clinical Oncology
2023;50(21):1098-1105
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical and pathological characteristics and prognostic factors of gastric neuroendocrine carcinoma(G-NEC)and gastric mixed adenoendocrine carcinoma(G-MANEC).Methods:Retrospective analysis was conducted on the clinical data of 67 patients with G-NEC and G-MANEC who underwent surgical treatment at Heping Hospital Affiliated to Changzhi Medical College from May 2015 to May 2023.The study included an analysis of the pathological characteristics distinguishing G-NEC from G-MANEC.Results:Com-pared to gastric adenocarcinoma,patients with G-NEC and G-MANEC in the stomach showed a higher incidence of gastric cancer in the male gastric cardia and were diagnosed at a later age.Tumors with larger diameters increase susceptibility to anemia,low albumin levels,and in-vasion of nerves and vasculature.Deeper tumor infiltration is associated with increased local lymph node metastases,later TNM staging,and a higher likelihood of distant metastasis post-surgery.The prognosis of G-NEC and G-MANEC is worse than that of gastric adenocarcinoma(P=0.001).However,there is no statistically significant difference in the pathological characteristics(P>0.05)and prognosis analysis(P=0.212)between G-NEC and G-MANEC.Univariate survival analysis identified age,preoperative albumin,preoperative CEA,number of lymph node metastases,TNM staging,and postoperative distant metastasis as risk factors affecting patient's overall survival(OS).In the multivariate ana-lysis,age,preoperative albumin,TNM staging,and postoperative distant metastasiswere identified as independent risk factors for OS.Con-clusions:There is a significant difference in clinical characteristics between G-NEC,G-MANEC,and gastric adenocarcinoma,often diagnosed at an advanced stage,which is prone to distant metastasis post-surgery.Poor prognosis is observed in patients aged over 60 years,with pre-operative albumin<40g/L,TNM stage Ⅱ/Ⅲ,and postoperative distant metastasis.
