Research progress on the mechanism of nucleotide-binding oligomerization domain-like receptor family pyrin domain containing protein 3 inflammasomes mediating diabetes and its complications

VernacularTitle:核苷酸结合寡聚化结构域样受体家族含热蛋白结构域蛋白3炎症小体介导糖尿病及其并发症相关机制的研究进展
Author: Xiaojin HAN ¹ ; Junyao XIE ; Xiuping BAI
Author Information

1. 山西医科大学第二临床医学院，太原　030001
Keywords: Diabetes mellitus; Complication; Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing inflammasome; Inflammation; Mechan
From: Clinical Medicine of China 2024;40(2):145-152
CountryChina
Language:Chinese
Abstract: Diabetes mellitus is one of the common endocrine diseases in clinic, but its exact pathogenesis not yet been clarified. Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3(NLRP3) inflammasome can not only be activated by upstream signaling pathways, which plays an important role in pyroptosis, apoptosis, necrosis, autophagy, etc., but also regulate downstream inflammatory factors to participate in the chronic inflammatory process of diseases. This article elucidates the role of NLRP3 inflammasome in the pathogenesis or intervention of diabetes and its complications, and provides a new direction for research. NLRP3 inflammasome and its regulated cytokines or receptors may be a new diagnostic or therapeutic targets for diabetes and its complications.